Why Ras needs Rho

Frank McCormick ()
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Frank McCormick: the Cancer Center, University of California at San Francisco

Nature, 1998, vol. 394, issue 6690, 220-221

Abstract: The Rho protein is a small GTPase that, among its many functions, helps another small GTPase called Ras to transform cells to an oncogenic state. But which of Rho's functions is needed for this transformation? It turns out that Rho helps Ras by inhibiting another protein p21Waf1/Cip1. This protein normally inhibits the cell cycle, so, by preventing it from doing this, Rho enables Ras to carry out its function — driving cells into the cell cycle.

Date: 1998
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DOI: 10.1038/28268

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