The pathogen connection

Christophe Benoist () and Diane Mathis ()
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Christophe Benoist: the Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP) BP 163
Diane Mathis: the Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP) BP 163

Nature, 1998, vol. 394, issue 6690, 227-228

Abstract: The Coxsackie B virus has been linked to autoimmune diabetes, and there are two main theories to account for this. The first (molecular mimicry) predicts that pathogen-encoded antigens are similar to self-proteins, priming the immune system to attack self-tissues. The second (bystander activation) holds that the pathogen simply disrupts the equilibrium of self-tolerance, causing self-tissues that would otherwise have been ignored to be attacked. A new study comes down firmly in favour of the bystander-activation theory — for Coxsackie-virus-induced diabetes at least.

Date: 1998
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DOI: 10.1038/28282

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