Caught in the act of the switch-on

Fred Wittinghofer ()
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Fred Wittinghofer: the Max-Planck-Institut für Molekulare Physiologie

Nature, 1998, vol. 394, issue 6691, 317-319

Abstract: Ras is an especially important molecular switch —it is part of the machinery for transmitting signals for growth and other processes to the cell nucleus, and mutated forms are implicated in about 30% of human tumours. Further insight into how this switch is turned on comes from solution of the structure of Ras complexed with another protein, Sos, one of the factors essential for Ras action.

Date: 1998
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DOI: 10.1038/28492

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