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The original sin of killer T cells

Andrew J. McMichael ()
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Andrew J. McMichael: Institute of Molecular Medicine, John Radcliffe Hospital

Nature, 1998, vol. 394, issue 6692, 421-422

Abstract: The phrase ‘original antigenic sin’ was first used to describe the antibody response to influenza virus. After an initial infection, reinfection with a different strain of the virus boosted the concentration of antibodies specific for the earlier infecting strain. A new study shows that this is also the case for the response of cytotoxic T lymphocytes to lymphocytic choriomeningitis virus.

Date: 1998
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DOI: 10.1038/28738

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