Sticky fingers grab a lipid

Claudia Wiedemann () and Shamshad Cockcroft ()
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Claudia Wiedemann: Rockefeller Building, University College
Shamshad Cockcroft: Rockefeller Building, University College

Nature, 1998, vol. 394, issue 6692, 426-427

Abstract: Within the past ten years, inositol lipids have increasingly been implicated in membrane-transport processes. Three studies now show what connects one inositol lipid — phosphatidylinositol-3-phosphate, PtdIns(3)P — to endocytosis. It turns out that a protein called the early endosomal autoantigen EEA1 contains a domain called FYVE that can bind, specifically and directly, to PtdIns(P)3. What's more, EEA1 can also bind to Rab5, a protein involved in endocytosis.

Date: 1998
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DOI: 10.1038/28752

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