Awakening angels

David Lane ()
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David Lane: Cancer Research Campaign Laboratories, University of Dundee

Nature, 1998, vol. 394, issue 6694, 616-617

Abstract: When mammalian cells are under stress they activate the tumour-suppressor gene p53. But how does the cell signal to p53 that it is under attack? A new study implicates the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage and can bind p53. Damaged cells that don't contain DNA-PK accumulate an inactive form of p53, indicating that DNA-PK is crucial for the activation of p53.

Date: 1998
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DOI: 10.1038/29166

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