Marked for nuclear export?

Nullin Divecha ()
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Nullin Divecha: The Netherlands Cancer Institute

Nature, 1998, vol. 394, issue 6694, 619-620

Abstract: One of the ways in which external signals such as growth factors can deliver messages to the nucleus is through the secondary messenger diacylglycerol (DAG). DAG activates protein kinase C, which travels into the nucleus and interacts with nuclear targets. A new study shows that PKC can regulate its own activity in the nucleus through a feedback loop — PKC can inhibit the action of DGK-ζ, an enzyme that removes DAG.

Date: 1998
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DOI: 10.1038/29174

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