Burnet's unhappy hybrid

Klaus Rajewsky ()
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Klaus Rajewsky: Institute for Genetics, University of Köln

Nature, 1998, vol. 394, issue 6694, 624-625

Abstract: Almost 40 years ago, Burnet proposed his theory of clonal selection, whereby antibodies are precommitted to having a certain specificity before they ever come into contact with antigen. But two new papers reinforce previous evidence and show that antibody specificity can change after these early stages of development, in a process known as receptor editing.

Date: 1998
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DOI: 10.1038/29187

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