The stomach is a source of leptin

André Bado, Sandrine Levasseur, Samir Attoub, Stéphanie Kermorgant, Jean-Pierre Laigneau, Marie-Noëlle Bortoluzzi, Laurent Moizo, Thérèse Lehy, Michèle Guerre-Millo, Yannick Le Marchand-Brustel and Miguel. J. M. Lewin ()
Additional contact information
André Bado: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Samir Attoub: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Stéphanie Kermorgant: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Jean-Pierre Laigneau: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Marie-Noëlle Bortoluzzi: INSERM U145, Faculté de Médecine
Laurent Moizo: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Thérèse Lehy: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat
Michèle Guerre-Millo: INSERM U465, Institut des Cordeliers
Yannick Le Marchand-Brustel: INSERM U145, Faculté de Médecine
Miguel. J. M. Lewin: Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat

Nature, 1998, vol. 394, issue 6695, 790-793

Abstract: Abstract The circulating peptide leptin, which is the product of the ob gene1, provides feedback information on the size of fat stores to central Ob receptors2,3 that control food intake and body-weight homeostasis4,5,6. Leptin has so far been reported to be secreted only by adipocytes1 and the placenta7. Here we show that leptin messenger RNA and leptin protein are present in rat gastric epithelium, and that cells in the glands of the gastric fundic mucosa are immunoreactive for leptin. The physiological function of this previously unsuspected source of leptin is unknown. However, both feeding and administration of CCK-8 (the biologically active carboxy-terminal end of cholecystokinin) result in a rapid and large decrease in both leptin cell immunoreactivity and the leptin content of the fundic epithelium, with a concomitant increase in the concentration of leptin in the plasma. These results indicate that gastric leptin may be involved in early CCK-mediated effects activated by food intake, possibly including satiety.

Date: 1998
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DOI: 10.1038/29547

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