FGF-mediated mesoderm induction involves the Src-family kinase Laloo

Daniel C. Weinstein, Jennifer Marden, Francesca Carnevali and Ali Hemmati-Brivanlou ()
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Daniel C. Weinstein: The Rockefeller University
Jennifer Marden: The Rockefeller University
Francesca Carnevali: Centro di Studio per gli Acidi Nucleici, CNR, Universita di Roma La Sapienza
Ali Hemmati-Brivanlou: The Rockefeller University

Nature, 1998, vol. 394, issue 6696, 904-908

Abstract: Abstract During embryogenesis, inductive interactions underlie the development of much of the body plan. In Xenopus laevis, factors secreted from the vegetal pole induce mesoderm in the adjacent marginal zone; members of both the transforming growth factor-β (TGF-β) and fibroblast growth factor (FGF) ligand families seem to have critical roles in this process1. Here we report the identification and characterization of laloo, a novel participant in the signal transduction cascade linking extracellular, mesoderm-inducing signals to the nucleus, where alteration of cell fate is driven by changes in gene expression. Overexpression of laloo, a member of the Src-related gene family, in Xenopus embryos gives rise to ectopic posterior structures that frequently contain axial tissue. Laloo induces mesoderm in Xenopus ectodermal explants; this induction is blocked by reagents that disrupt the FGF signalling pathway. Conversely, expression of a dominant-inhibitory Laloo mutant blocks mesoderm induction by FGF and causes severe posterior truncations in vivo. This work provides the first evidence that a Src-related kinase is involved in vertebrate mesoderm induction.

Date: 1998
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DOI: 10.1038/29808

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