Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

Ying Zhang, Xin-Hua Feng and Rik Derynck ()
Additional contact information
Ying Zhang: University of California at San Francisco
Xin-Hua Feng: University of California at San Francisco
Rik Derynck: University of California at San Francisco

Nature, 1998, vol. 394, issue 6696, 909-913

Abstract: Abstract Smad proteins transduce signals for transforming growth factor-β (TGF-β)-related factors1. Smad proteins activated by receptors for TGF-β form complexes with Smad4. These complexes are translocated into the nucleus and regulate ligand-indu ced gene transcription2,3,4. 12- O-tetradecanoyl-13-acetate (TPA)-responsive gene promoter elements (TREs) are involved in the transcriptional responses of several genes to TGF-β (5–8). AP-1 transcription factors, composed of c-Jun and c-Fos, bind to and direct transcription from TREs, which are therefore known as AP1-binding sites9. Here we show that Smad3 interacts directly with the TRE and that Smad3 and Smad4 can activate TGF-β-inducible transcription from the TRE in the absence of c-Jun and c-Fos. Smad3 and Smad4 also act together with c-Jun and c-Fos to activate transcription in response to TGF-β, through a TGF-β-inducible association of c-Jun with Smad3 and an interaction of Smad3 and c-Fos. These interactions complement interactions between c-Jun and c-Fos, and between Smad3 and Smad4. This mechanism of transcriptional activation by TGF-β, through functional and physical interactions between Smad3–Smad4 and c-Jun–c-Fos, shows that Smad signalling and MAPK/JNK signalling converge at AP1-binding promoter sites.

Date: 1998
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/29814 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:394:y:1998:i:6696:d:10.1038_29814

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/29814

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().