Has the smart bomb been defused?

Steven P. Linke ()
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Steven P. Linke: the Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health

Nature, 1998, vol. 395, issue 6697, 13-15

Abstract: Most cancer therapies aim to destroy tumour cells, leaving the surrounding normal cells untouched. This is the basis of one treatment, involving a mutated adenovirus that is thought to destroy only those cells that lack the tumour-suppressor protein p53. But new research indicates that the adenovirus may actually require p53 to replicate, meaning that it would instead target healthy cells.

Date: 1998
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DOI: 10.1038/25595

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