Turning off follicular dendritic cells

Fabienne Mackay () and Jeffrey L. Browning
Additional contact information
Fabienne Mackay: Inflammation and Cell Biology, Biogen
Jeffrey L. Browning: Inflammation and Cell Biology, Biogen

Nature, 1998, vol. 395, issue 6697, 26-27

Abstract: Abstract Follicular dendritic cells (FDCs) are specialized to display intact antigens for recognition by B cells. Here we show that inhibition of lymphotoxin α/β (LTα/β) leads to the disappearance of multiple markers on FDCs within one day, regardless of whether any immune reactions are taking place. Inhibition of the tumour necrosis factor (TNF) pathway was also effective, but only in the absence of a strong antigenic response. These treatments not only prevented trapping of newly formed immune complexes, but also eliminated previously trapped immune complexes on FDCs, rendering the FDC non-functional. Therefore lymphotoxin and/or TNF is required for the continual maintenance of FDC function.

Date: 1998
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/25630 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:395:y:1998:i:6697:d:10.1038_25630

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/25630

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().