Casting an eye over cyclopia

Patrick Blader () and Uwe Strähle ()
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Patrick Blader: Institut de Génétique et de la Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP163
Uwe Strähle: Institut de Génétique et de la Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP163

Nature, 1998, vol. 395, issue 6698, 112-113

Abstract: Cyclopia — the development of a single, central eye — occurs because of a lack of, or defect in, development of the ventral (fore) brain. Three groups have studied this developmental pathway in the zebrafish, and have identified two of the genes involved. Fish that lack the cyclops (cyc) and squint (sqt) genes are cyclopic. Moreover, the authors have found that Cyclops belongs to the transforming growth factor-β family of proteins.

Date: 1998
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DOI: 10.1038/25836

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