Purposeful mutations
Myron F. Goodman ()
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Myron F. Goodman: Program in Molecular Biology, Stauffer Hall of Science 172, University of Southern California
Nature, 1998, vol. 395, issue 6699, 221-223
Abstract:
When DNA is damaged, repair systems exist to remove lesions and fill in gaps. So when that DNA is replicated, the original sequence will be passed on to daughter cells. ButEscherichia colicontains proteins that do just the opposite -- they reduce replication fidelity. The study of these proteins should now be easier, thanks to in vitrosystems developed by two groups, that reconstitute this so-called error-prone repair.
Date: 1998
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DOI: 10.1038/26111
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