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Docking IκB kinases

Claus Scheidereit ()
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Claus Scheidereit: the Max-Delbrück-Centrum für Molekulare Medizin

Nature, 1998, vol. 395, issue 6699, 225-226

Abstract: The transcription factor NF-κB is activated in response to, among other things, stress. Normally, NF-κB is repressed by a protein called IκB which, in turn, is switched off by two protein kinases. Two studies now add another piece to the pathway, by showing that the interaction between all of these players could be facilitated by 'docking' proteins, which act as a kind of scaffolding.

Date: 1998
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DOI: 10.1038/26121

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