Does vitamin C have a pro-oxidant effect?

Henrik E. Poulsen (), Allan Weimann, Jukka T. Salonen, Kristiina Nyyssönen, Steffen Loft, Jean Cadet, Thierry Douki and Jean-Luc Ravanat
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Henrik E. Poulsen: Rigshospitalet, University of Copenhagen
Allan Weimann: Rigshospitalet, University of Copenhagen
Jukka T. Salonen: Research Institute of Public Health, University of Kuopio
Kristiina Nyyssönen: Research Institute of Public Health, University of Kuopio
Steffen Loft: Institute of Public Health, University of Copenhagen
Jean Cadet: DRFMC/SCIB, Laboratoire Lésions des Acides Nucléiques, CEA/Grenoble
Thierry Douki: DRFMC/SCIB, Laboratoire Lésions des Acides Nucléiques, CEA/Grenoble
Jean-Luc Ravanat: DRFMC/SCIB, Laboratoire Lésions des Acides Nucléiques, CEA/Grenoble

Nature, 1998, vol. 395, issue 6699, 231-232

Abstract: Abstract Podmore et al.1 reported a decrease in 8-oxo-7,8-dihydroguanine and an increase in 8-oxo-7,8-dihydroadenine in lympho-cyte DNA after intake of 500 milligrams of vitamin C daily for 6 weeks. In our view, four issues compromise the validity of their findings.

Date: 1998
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DOI: 10.1038/26139

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