Does vitamin C have a pro-oxidant effect?

Ian D. Podmore (), Helen R. Griffiths, Karl E. Herbert, Nalini Mistry, Pratibha Mistry and Joseph Lunec
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Ian D. Podmore: Centre for Mechanisms of Human Toxicity, University of Leicester
Helen R. Griffiths: Centre for Mechanisms of Human Toxicity, University of Leicester
Karl E. Herbert: Centre for Mechanisms of Human Toxicity, University of Leicester
Nalini Mistry: Centre for Mechanisms of Human Toxicity, University of Leicester
Pratibha Mistry: Centre for Mechanisms of Human Toxicity, University of Leicester
Joseph Lunec: Centre for Mechanisms of Human Toxicity, University of Leicester

Nature, 1998, vol. 395, issue 6699, 232-232

Abstract: Abstract Podmore et al. reply — In our Scientific Correspondence 1 we reported changes in lymphocyte DNA to two established ‘markers’ of oxidative DNA damage after daily supplementation of healthy volunteers with 500 mg vitamin C for six weeks. One marker, 8-oxoadenine, increased, whereas the other, 8-oxoguanine, decreased. On this basis, vitamin C seems to act as both a pro-oxidant and an antioxidant in vivo. Our contribution has stimulated many comments, most of which were addressed in our original manuscript to Nature, which was shortened for publication at the editors' request. The full details are available from us on request.

Date: 1998
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DOI: 10.1038/26141

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