Sighting of the swinging lever arm of muscle

Maxine Clarke

Nature, 1998, vol. 395, issue 6701, 443-443

Abstract: How do motor proteins such as myosin convert chemical force to mechanical force? The crystal structure of myosin's motor domain should give us some clues, allowing us to see, for the first time, the muscle's power stroke. The structure supports the theory that myosin has a ‘lever arm’, which rotates when ATP binds and is hydrolysed.

Date: 1998
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DOI: 10.1038/26629

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