Two orphans find a home

Didier Picard ()
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Didier Picard: Université de Genève

Nature, 1998, vol. 395, issue 6702, 543-544

Abstract: Many members of the nuclear-receptor superfamily are turned on by ligands that, as yet, have not been identified. One such 'orphan' receptor, the constitutively active receptor, has now been 'adopted' by not one, but two ligands, leading it to be renamed the 'constitutive androstane receptor'. Moreover, the ligands turn the receptor off — just the opposite of what ligands usually do to nuclear receptors.

Date: 1998
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DOI: 10.1038/26850

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