Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Robert A. Cavallo, Rachel T. Cox, Melissa M. Moline, Jeroen Roose, Gordon A. Polevoy, Hans Clevers, Mark Peifer and Amy Bejsovec ()
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Robert A. Cavallo: University of North Carolina
Rachel T. Cox: University of North Carolina
Melissa M. Moline: Molecular Biology and Cell Biology, Northwestern University
Jeroen Roose: University Hospital
Gordon A. Polevoy: University of North Carolina
Hans Clevers: University Hospital
Mark Peifer: University of North Carolina
Amy Bejsovec: Molecular Biology and Cell Biology, Northwestern University

Nature, 1998, vol. 395, issue 6702, 604-608

Abstract: Abstract Wingless/Wnt signalling directs cell-fate choices during embryonic development1,2. Inappropriate reactivation of the pathway causes cancer3,4,5. In Drosophila, signal transduction from Wingless stabilizes cytosolic Armadillo1, which then forms a bipartite transcription factor with the HMG-box protein Drosophila Tcf (dTcf) and activates expression of Wingless-responsive genes6,7,8. Here we report that in the absence of Armadillo, dTcf acts as a transcriptional repressor of Wingless-responsive genes, and we show that Groucho acts as a corepressor in this process. Reduction of dTcf activity partially suppresses wingless and armadillo mutant phenotypes, leading to derepression of Wingless-responsive genes. Furthermore, overexpression of wild-type dTcf enhances the phenotype of a weak wingless allele. Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity.

Date: 1998
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DOI: 10.1038/26982

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