Effects of progesterone or neuroactive steroid?

Sheryl S. Smith, Qi Hua Gong, Fu-Chun Hsu, Ronald S. Markowitz, J. M. H. ffrench-Mullen and Xinshe Li
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Sheryl S. Smith: Allegheny University of the Health Sciences
Qi Hua Gong: Allegheny University of the Health Sciences
Fu-Chun Hsu: Allegheny University of the Health Sciences
Ronald S. Markowitz: Allegheny University of the Health Sciences
J. M. H. ffrench-Mullen: RIN Bioscience, Zeneca Pharmaceuticals
Xinshe Li: Allegheny University of the Health Sciences

Nature, 1998, vol. 395, issue 6703, 652-653

Abstract: Abstract Smith et al. reply — Morrow et al.are incorrect to state that we did not provide direct evidence that 3α-OH-5α-pregnan-20-one (3α,5α-THP, or allopregnanolone) levels were reduced by indomethacin. We pointed out1 that our previous studies7 showed that indomethacin administration concomitant with progesterone reduced the level of 3α,5α-THP in the central nervous system from 8.2 6 1.3 ng per g to 2.3 0.35 ng per g without altering levels of 5α-DHP or progesterone. This treatment, which prevented the withdrawal of 3α,5α-THP that normally accompanies progesterone withdrawal, completely prevented the withdrawal effects of progesterone we observed1, including acceleration in the decay of GABA-gated current and upregulation of the GABAA-receptor α4 subunit.

Date: 1998
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DOI: 10.1038/27109

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