The clash in titin

Anthony R. Means ()
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Anthony R. Means: Duke University Medical Center

Nature, 1998, vol. 395, issue 6705, 846-847

Abstract: The gigantic muscle protein titin is a scaffold upon which the contractile units of striated muscle are assembled. Its catalytic domain is a protein kinase, and this region has now been crystallized. The structure reveals several surprises about the function of the titin kinase, and should help us to work out how this enzyme is regulated.

Date: 1998
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DOI: 10.1038/27557

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