Mice without myoglobin

Daniel J. Garry, George A. Ordway, John N. Lorenz, Nina B. Radford, Eva R. Chin, Robert W. Grange, Rhonda Bassel-Duby and R. Sanders Williams ()
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Daniel J. Garry: Departments of Internal Medicine
George A. Ordway: Departments of Physiology
John N. Lorenz: University of Cincinnati
Nina B. Radford: Departments of Internal Medicine
Eva R. Chin: Departments of Internal Medicine
Robert W. Grange: Departments of Physiology
Rhonda Bassel-Duby: Departments of Internal Medicine
R. Sanders Williams: Departments of Internal Medicine

Nature, 1998, vol. 395, issue 6705, 905-908

Abstract: Abstract Myoglobin, an intracellular haemoprotein expressed in the heart and oxidative skeletal myofibres of vertebrates, binds molecular oxygen and may facilitate oxygen transport from erythrocytes to mitochondria, thereby maintaining cellular respiration during periods of high physiological demand1,2,3,4,5,6,7,8,9,10. Here we show, however, that mice without myoglobin, generated by gene-knockout technology, are fertile and exhibit normal exercise capacity and a normal ventilatory response to low oxygen levels (hypoxia). Heart and soleus muscles from these animals are depigmented, but function normally in standard assays of muscle performance invitro across a range of work conditions and oxygen availability. These data show that myoglobin is not required to meet the metabolic requirements of pregnancy or exercise in a terrestrial mammal, and raise new questions about oxygen transport and metabolic regulation in working muscles.

Date: 1998
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DOI: 10.1038/27681

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