Attractive genetics

Ken Howard ()
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Ken Howard: University College London

Nature, 1998, vol. 396, issue 6710, 406-407

Abstract: During development, the precursors for eggs and sperm — the germ cells — migrate to the gonads to mature. But what attracts them there? Results from a fruitfly screen indicate that one component in this pathway is a gene calledcolumbus, which encodes HMG-CoA reductase. In humans, this enzyme is involved in cholesterol biosynthesis, raising the intriguing possibility that the attractant may be a lipid.

Date: 1998
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DOI: 10.1038/24714

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