Is bigger better?

Robert C. Malenka () and Roger A. Nicoll ()
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Robert C. Malenka: University of California
Roger A. Nicoll: University of California

Nature, 1998, vol. 396, issue 6710, 414-415

Abstract: There is plenty of indirect evidence that the postsynaptic density (PSD)-95 protein is involved in the clustering and, perhaps, targeting of postsynaptic proteins. Direct evidence was lacking, but PSD-95 knockout mice have now arrived, and their properties support a clustering function. However, knocking out PSD-95 also disrupts synaptic plasticity, and this could mean that PSD-95 acts as a kind of scaffold protein.

Date: 1998
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DOI: 10.1038/24734

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