p53 polymorphism and risk of cervical cancer

Åslaug Helland, Anita Langerød, Hilde Johnsen, Anne O. Olsen, Eva Skovlund and Anne-Lise Børresen-Dale ()
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Åslaug Helland: Institute of Cancer Research, Norwegian Radium Hospital
Anita Langerød: Institute of Cancer Research, Norwegian Radium Hospital
Hilde Johnsen: Institute of Cancer Research, Norwegian Radium Hospital
Anne O. Olsen: Section of Epidemiology, National Institute of Public Health
Eva Skovlund: University of Oslo
Anne-Lise Børresen-Dale: Institute of Cancer Research, Norwegian Radium Hospital

Nature, 1998, vol. 396, issue 6711, 530-531

Abstract: Abstract Storey and co-workers 1 recently presented results indicating that the allele encoding arginine in the codon-72 polymorphism of the p53 gene represents a significant risk factor in the development of cancers associated with human papilloma virus (HPV). The form of the p53 protein carrying an arginine residue at this position was found to be significantly more susceptible to degradation by the HPV E6 protein than by the proline form. Genotype analysis of 30 cervical tumours and 12 skin carcinomas revealed that the homozygous Arg/Arg genotype was overrepresented compared with 41 controls. We have now analysed this polymorphism in leukocyte DNA from a larger sample of cancer patients and controls but have found no significant overrepresentation of this genotype.

Date: 1998
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DOI: 10.1038/25034

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