p53 polymorphism and risk of cervical cancer

Allan Hildesheim, Mark Schiffman, Louise A. Brinton, Joseph F. Fraumeni, Rolando Herrero, M. Concepcion Bratti, Peter Schwartz, Rodrigue Mortel, Willard Barnes, Mitchell Greenberg, Larry McGowan, David R. Scott, Maureen Martin, Jesus E. Herrera and Mary Carrington
Additional contact information
Allan Hildesheim: National Cancer Institute
Mark Schiffman: National Cancer Institute
Louise A. Brinton: National Cancer Institute
Joseph F. Fraumeni: National Cancer Institute
Rolando Herrero: International Agency for Research on Cancer
M. Concepcion Bratti: Caja Costarriciense de Seguro Social
Peter Schwartz: Yale University School of Medicine
Rodrigue Mortel: Milton S. Hershey Medical Center
Willard Barnes: Georgetown University Lombardi Cancer Center
Mitchell Greenberg: Graduate Hospital
Larry McGowan: George Washington University Medical Center
David R. Scott: Kaiser Permanente
Maureen Martin: Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC
Jesus E. Herrera: Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC
Mary Carrington: Intramural Research Support Program, SAIC-Frederick, National Cancer Institute-FCRDC

Nature, 1998, vol. 396, issue 6711, 531-532

Abstract: Abstract Storey and co-workers 1 have reported data suggesting that individuals homozygous for arginine at residue 72 of p53 (p53Arg) are about seven times more susceptible to invasive cervical cancer than individuals who carry at least one proline at that position (p53Pro)1. These preliminary data were supported by in vitro evidence demonstrating that the E6 oncoprotein of human papilloma virus (HPV) degrades p53Arg more efficiently than p53Pro. We have now tested specimens from a total of 1,309 women in three studies for p53 polymorphisms. We find that p53Arg is not associated with an increased risk of preinvasive or invasive cervical neoplasia; indeed, there is a tendency for p53Arg to be associated with a decreased risk of neoplasia.

Date: 1998
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DOI: 10.1038/25040

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