The ABC of a versatile engine

Michael J. Welsh (), Andrew D. Robertson and Lynda S. Ostedgaard
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Michael J. Welsh: the University of Iowa College of Medicine
Andrew D. Robertson: the University of Iowa College of Medicine
Lynda S. Ostedgaard: the University of Iowa College of Medicine

Nature, 1998, vol. 396, issue 6712, 623-624

Abstract: The ATP-binding cassette (ABC) transporter family of proteins all contain two nucleotide-binding domains (NBDs) along with two membrane-spanning domains. The NBDs are molecular engines, and the crystal structure of one -- the NBD from theSalmonella typhimuriumhistidine permease -- now gives us clues about how the NBDs work. The results have implications for other ABC transporters, including the protein that is mutated in cystic fibrosis.

Date: 1998
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DOI: 10.1038/25234

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