A protease draws first blood

Matthew Bogyo and Hidde L. Ploegh ()
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Matthew Bogyo: Harvard Medical School
Hidde L. Ploegh: Harvard Medical School

Nature, 1998, vol. 396, issue 6712, 625-627

Abstract: Foreign proteins in a cell are chopped up and presented to the immune system by molecules of the major histocompatibility complex. What enzymes are responsible for making these cuts? The enzyme that delivers the initial blow specifically to the tetanus toxin has now been identified as asparaginyl endopeptidase.

Date: 1998
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DOI: 10.1038/25238

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