Death deceiver

Douglas R. Green ()
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Douglas R. Green: the La Jolla Institute for Allergy and Immunology

Nature, 1998, vol. 396, issue 6712, 629-630

Abstract: Tumours develop because the tumour cells are immortal -- they escape cell-killing mechanisms. Normally, when a molecule called Fas binds its ligand (FasL), a death pathway (apoptosis) is activated. But another molecule called DcR3, which has now been identified in lung and colon carcinomas, can also bind FasL, blocking the apoptotic pathway and allowing tumour cells to cheat death.

Date: 1998
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DOI: 10.1038/25248

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