Immobile plasticizer in flexible PVC

A. Jayakrishnan () and S. Lakshmi ()
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A. Jayakrishnan: Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences Technology
S. Lakshmi: Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences Technology

Nature, 1998, vol. 396, issue 6712, 638-638

Abstract: Abstract Plasticized poly(vinyl chloride) (PVC) is one of the most widely used polymeric materials in medical and related applications, and usually contains up to 40 per cent di-(2-ethylhexyl)phthalate (DEHP), which acts as the ‘plasticizer’ to impart flexibility to an otherwise rigid PVC1. The plasticizer can migrate from PVC-based devices and storage bags into physiological fluids, however, and has been detected in storage media such as blood, plasma, serum, drug solutions and fatty foods2,3,4, as well as in the bodies of patients undergoing haemodialysis and transfusion5. This is a concern because DEHP is a lipid-removing liver carcinogen6, and causes hepatic7 and reproductive toxicity8 in rodents, although opinion is divided on its toxicity in humans9.

Date: 1998
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DOI: 10.1038/25275

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