An anchor for activation

Peter ten Dijke () and Carl-Henrik Heldin ()
Additional contact information
Peter ten Dijke: the Ludwig Institute for Cancer Research
Carl-Henrik Heldin: the Ludwig Institute for Cancer Research

Nature, 1999, vol. 397, issue 6715, 109-111

Abstract: The first step in signalling through the transforming growth factor (TGF)-β pathway involves phosphorylation of either Smad2 or Smad3 by an activated type-I receptor kinase. How do TGF-β, the receptor and the Smad manage to meet up? The answer is a newly discovered ‘anchor’ protein termed SARA, which recruits the Smads to the TGF-β receptor.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/16357 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:397:y:1999:i:6715:d:10.1038_16357

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/16357

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().