Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

Richard A. Alm (), Lo-See L. Ling, Donald T. Moir, Benjamin L. King, Eric D. Brown, Peter C. Doig, Douglas R. Smith, Brian Noonan, Braydon C. Guild, Boudewijn L. deJonge, Gilles Carmel, Peter J. Tummino, Anthony Caruso, Maria Uria-Nickelsen, Debra M. Mills, Cameron Ives, Rene Gibson, David Merberg, Scott D. Mills, Qin Jiang, Diane E. Taylor, Gerald F. Vovis and Trevor J. Trust
Additional contact information
Richard A. Alm: Astra Research Center Boston
Lo-See L. Ling: Genome Therapeutics Corporation
Donald T. Moir: Genome Therapeutics Corporation
Benjamin L. King: Astra Research Center Boston
Eric D. Brown: Astra Research Center Boston
Peter C. Doig: Astra Research Center Boston
Douglas R. Smith: Genome Therapeutics Corporation
Brian Noonan: Astra Research Center Boston
Braydon C. Guild: Genome Therapeutics Corporation
Boudewijn L. deJonge: Astra Research Center Boston
Gilles Carmel: Genome Therapeutics Corporation
Peter J. Tummino: Astra Research Center Boston
Anthony Caruso: Genome Therapeutics Corporation
Maria Uria-Nickelsen: Astra Research Center Boston
Debra M. Mills: Genome Therapeutics Corporation
Cameron Ives: Astra Research Center Boston
Rene Gibson: Genome Therapeutics Corporation
David Merberg: Astra Research Center Boston
Scott D. Mills: Astra Research Center Boston
Qin Jiang: University of Alberta
Diane E. Taylor: University of Alberta
Gerald F. Vovis: Genome Therapeutics Corporation
Trevor J. Trust: Astra Research Center Boston

Nature, 1999, vol. 397, issue 6715, 176-180

Abstract: Abstract Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma1. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host2,3 and to participate in the lifelong chronicity of infection4. Here we compare the complete genomic sequences of two unrelated H. pylori isolates. This is, to our knowledge, the first such genomic comparison. H. pylori was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.

Date: 1999
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DOI: 10.1038/16495

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