A homeostatic switch

Richard Miles ()
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Richard Miles: Laboratoire de Neurobiologie Cellulaire, INSERM U261, Institut Pasteur

Nature, 1999, vol. 397, issue 6716, 215-216

Abstract: During development, some neurons can change their sensitivity to neurotransmitters such as GABA. At birth, these neurons contain high concentrations of Cl− ions, which means that GABA excites them. But just a week after birth, they contain much less intracellular Cl−, and GABA is inhibitory. The protein responsible for this switch has now been identified, and is shown to be a K+/Cl−co-transporter called KCC2.

Date: 1999
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DOI: 10.1038/16604

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