Fas-mediated cell death promoted by opioids

Deling Yin, R. Allan Mufson, Ruoxiang Wang and Yufang Shi ()
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Deling Yin: Jerome H. Holland Laboratory for Biomedical Sciences, American Red Cross
R. Allan Mufson: National Cancer Institute
Ruoxiang Wang: Jerome H. Holland Laboratory for Biomedical Sciences, American Red Cross
Yufang Shi: Jerome H. Holland Laboratory for Biomedical Sciences, American Red Cross

Nature, 1999, vol. 397, issue 6716, 218-218

Abstract: Abstract Opioids have been used as potent analgesics for centuries, but their abuse has deleterious physiological effects beyond addiction1 — for instance, they can somehow alter the function of the immune system2. Here we show that morphine induces the expression of the protein Fas (also known as CD95 or APO-1), a receptor on the cell surface that triggers the cell's suicide by apoptosis when it binds to its ligand, FasL. This induction of Fas expression by opioids appears to prime lymphocytes for elimination by apoptosis.

Date: 1999
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DOI: 10.1038/16612

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