Yeast cell-type regulation of DNA repair

Stefan U. Åström, Sara M. Okamura and Jasper Rine ()
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Stefan U. Åström: Ume University
Sara M. Okamura: University of California, Berkeley
Jasper Rine: University of California, Berkeley

Nature, 1999, vol. 397, issue 6717, 310-310

Abstract: Abstract The mating-type locus (MAT) in the yeast Saccharomyces cerevisiae provides information about whether cells are of the a or α mating type, and genes at this locus encode transcriptional regulators that determine the phenotypes associated with the different cell types1. In a/α diploid cells, the a1/α2 repressor is formed, which inhibits haploid-specific gene expression and indirectly promotes meiosis. Mutations in SIR (silent information regulator) genes cause a loss of both heterochromatin and transcriptional silencing, resulting in the expression of cryptic a and α genes resident at the HML and HMR loci. As a result, sir mutant strains have the properties of a/α diploids.

Date: 1999
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DOI: 10.1038/16833

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