OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms, Casey Capparelli, Sean Morony, Antonio J. Oliveira-dos-Santos, Gwyneth Van, Annick Itie, Wilson Khoo, Andrew Wakeham, Colin R. Dunstan, David L. Lacey, Tak W. Mak, William J. Boyle and Josef M. Penninger ()
Additional contact information
Young-Yun Kong: Ontario Cancer Institute, University of Toronto
Hiroki Yoshida: Ontario Cancer Institute, University of Toronto
Ildiko Sarosi: Amgen Inc., One Amgen Center Drive
Hong-Lin Tan: Amgen Inc., One Amgen Center Drive
Emma Timms: Amgen Inc., One Amgen Center Drive
Casey Capparelli: Amgen Inc., One Amgen Center Drive
Sean Morony: Amgen Inc., One Amgen Center Drive
Antonio J. Oliveira-dos-Santos: Ontario Cancer Institute, University of Toronto
Gwyneth Van: Amgen Inc., One Amgen Center Drive
Annick Itie: Ontario Cancer Institute, University of Toronto
Wilson Khoo: Ontario Cancer Institute, University of Toronto
Andrew Wakeham: Ontario Cancer Institute, University of Toronto
Colin R. Dunstan: Amgen Inc., One Amgen Center Drive
David L. Lacey: Amgen Inc., One Amgen Center Drive
Tak W. Mak: Ontario Cancer Institute, University of Toronto
William J. Boyle: Amgen Inc., One Amgen Center Drive
Josef M. Penninger: Ontario Cancer Institute, University of Toronto

Nature, 1999, vol. 397, issue 6717, 315-323

Abstract: Abstract The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro. Mice with a disrupted opgl gene show severe osteopetrosis and a defect in tooth eruption, and completely lack osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis. Although dendritic cells appear normal, opgl-deficient mice exhibit defects in early differentiation of T and B lymphocytes. Surprisingly, opgl-deficient mice lack all lymph nodes but have normal splenic structure and Peyer's patches. Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.

Date: 1999
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DOI: 10.1038/16852

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