Secondary V(D)J recombination in B-1 cells

Xiao-Feng Qin, Stephan Schwers, Wong Yu, Fotini Papavasiliou, Heikyung Suh, Andre Nussenzweig, Klaus Rajewsky and Michel C. Nussenzweig ()
Additional contact information
Xiao-Feng Qin: Laboratory of Molecular Immunology, The Rockefeller University
Stephan Schwers: Institute for Genetics, University of Cologne
Wong Yu: Laboratory of Molecular Immunology, The Rockefeller University
Fotini Papavasiliou: Laboratory of Molecular Immunology, The Rockefeller University
Heikyung Suh: Laboratory of Molecular Immunology, The Rockefeller University
Andre Nussenzweig: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
Klaus Rajewsky: Institute for Genetics, University of Cologne
Michel C. Nussenzweig: Laboratory of Molecular Immunology, The Rockefeller University

Nature, 1999, vol. 397, issue 6717, 355-359

Abstract: Abstract B-1 B cells are a self-renewing population of B cells that differ from conventional B cells (B-2 cells) in that they are particularly predisposed to auto-antibody production1,2,3. Although much is known about the signalling pathways that control B-1-cell growth and development (reviewed in ref. 4), less is known about why these cells are prone to produce autoreactive antibodies. Here we show that B-1 cells, like germinal-centre B cells5,6,7,8, can express recombinase-activating genes 1 and 2 (RAG1 and RAG2) and undergo secondary V(D)J recombination of immunoglobulin genes. In addition, B cells from autoimmune-prone NZB mice show high levels of RAG messenger RNA and recombination. We propose that secondary immunoglobulin-gene rearrangements outside organized lymphoid organs may contribute to the development of autoreactive antibodies.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/16933 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:397:y:1999:i:6717:d:10.1038_16933

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/16933

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().