A cellular poison cupboard

William C. Earnshaw ()
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William C. Earnshaw: the Institute of Cell and Molecular Biology, University of Edinburgh

Nature, 1999, vol. 397, issue 6718, 387-389

Abstract: Apoptotic cell death is driven by two classes of caspase — one to initiate the response and the other to carry it out. But initiator caspases can also activate death-promoting factors from the mitochondria. One of these is cytochrome c and another, the apoptosis-inducing factor, has now been identified. Both reside in the space between the inner and outer mitochondrial membranes, flagging this compartment as an important store of death factors.

Date: 1999
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DOI: 10.1038/17015

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