New way to activate caspases

Erkki Ruoslahti () and John Reed ()
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Erkki Ruoslahti: the Burnham Institute
John Reed: the Burnham Institute

Nature, 1999, vol. 397, issue 6719, 479-480

Abstract: Most cells need to be attached, through integrins, to a semi-solid meshwork called the extracellular matrix in order to survive. But if peptides with the sequence arginine-glycine-aspartic acid are added, the cells detach and die. The reason was always thought to be a blockade of integrin signalling, but a new mechanism has emerged. It seems that the RGD peptide activates caspases directly inside the cell.

Date: 1999
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DOI: 10.1038/17229

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