The amazing demethylase

Howard Cedar () and Gregory L. Verdine ()
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Howard Cedar: Hebrew University Medical School
Gregory L. Verdine: Harvard University

Nature, 1999, vol. 397, issue 6720, 568-569

Abstract: DNA methylation is important for repressing gene expression, and much is known about how methyl groups are added to DNA. But little has been done to work out how they're taken off again. Now, a hitherto unknown gene has been cloned, which encodes a protein that seems to catalyse demethylation by directly removing the methyl groups from 5-methyl-cytosine.

Date: 1999
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DOI: 10.1038/17492

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