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Hox proteins reach out round DNA

Matthew P. Scott ()
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Matthew P. Scott: Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 1999, vol. 397, issue 6721, 649-651

Abstract: Hox proteins are transcription factors that operate during the development of different tissues. The structure has now been determined of a complex between DNA, a Hox protein and its cofactor. The homeodomains of the two proteins bind to opposite sides of the DNA but make contact through a short length of the Hox protein that reaches round the DNA to insert itself into a pocket on the cofactor, thereby strengthening the complex.

Date: 1999
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DOI: 10.1038/17685

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