Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

Yoshifumi Yokota (), Ahmed Mansouri, Seiichi Mori, Seiichi Sugawara, Satoko Adachi, Shin-Ichi Nishikawa and Peter Gruss
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Yoshifumi Yokota: Max-Planck Institute of Biophysical Chemistry
Ahmed Mansouri: Max-Planck Institute of Biophysical Chemistry
Seiichi Mori: Graduate School of Medicine, Kyoto University
Seiichi Sugawara: Graduate School of Medicine, Kyoto University
Satoko Adachi: Graduate School of Medicine, Kyoto University
Shin-Ichi Nishikawa: Graduate School of Medicine, Kyoto University
Peter Gruss: Max-Planck Institute of Biophysical Chemistry

Nature, 1999, vol. 397, issue 6721, 702-706

Abstract: Abstract Transcription factors with a basic helix–loop–helix (HLH) motif have been shown to be crucial for various cell differentiation processes during development of multicellular organisms1. Id proteins inhibit the functions of these transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains2,3,4. Members of the Id family also promote cell proliferation4,5, implying a role in the control of cell differentiation. Here we show that Id2 is indispensable for normal development of mice. Id2−/− mice lack lymph nodes and Peyer's patches. However, their splenic architecture is normal, exhibiting T-cell and B-cell compartments and distinct germinal centres. The cell population that produces lymphotoxins, essential factors for the development of secondary lymphoid organs6,7,8,9,10,11, is barely detectable in the Id2−/− intestine. Furthermore, the null mutants show a greatly reduced population of natural killer (NK) cells, which is due to an intrinsic defect in NK-cell precursors. Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells.

Date: 1999
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DOI: 10.1038/17812

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