An SH2 domain in disguise

John Kuriyan () and James E. Darnell
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John Kuriyan: Howard Hughes Medical Institute
James E. Darnell: Laboratory of Molecular Cell Biology, Rockefeller University

Nature, 1999, vol. 398, issue 6722, 22-23

Abstract: Proteins inside cells that convey information from the outside often contain special signalling modules known as SH2 domains. These domains may have developed during the evolution of multicellular animals, and were typically identified by their amino-acid sequence. But now one has been discovered in a human protein called Cbl that has a quite different sequence, raising questions about the ancestral origin of these domains.

Date: 1999
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DOI: 10.1038/17916

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