DREAM on without calcium

Gail Mandel () and Richard H. Goodman
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Gail Mandel: Howard Hughes Medical Institute, State University of New York
Richard H. Goodman: Vollum Institute, Oregon Health Sciences University

Nature, 1999, vol. 398, issue 6722, 29-30

Abstract: One way of switching on certain genes to express their encoded proteins is to increase the concentration of calcium ions inside the cell nucleus, which can happen in response to an instruction from outside the cell. A new mediator of this effect has been discovered: it is a protein called DREAM, which sits tightly on the gene, preventing its expression, until it has bound four calcium ions. It then detaches itself, leaving the gene exposed for transcription.

Date: 1999
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DOI: 10.1038/17933

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