Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

Luis J. Sigal, Shane Crotty, Raul Andino and Kenneth L. Rock ()
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Luis J. Sigal: University of Massachusetts Medical Center
Shane Crotty: University of California
Raul Andino: University of California
Kenneth L. Rock: University of Massachusetts Medical Center

Nature, 1999, vol. 398, issue 6722, 77-80

Abstract: Abstract Cytotoxic T lymphocytes (CTLs) are thought to detect viral infections by monitoring the surface of all cells for the presence of viral peptides bound to major histocompatibility complex (MHC) class I molecules. In most cells, peptides presented by MHC class I molecules are derived exclusively from proteins synthesized by the antigen-bearing cells1. Macrophages and dendritic cells also have an alternative MHC class I pathway that can present peptides derived from extracellular antigens; however, the physiological role of this process is unclear2. Here we show that virally infected non-haematopoietic cells are unable to stimulate primary CTL-mediated immunity directly. Instead, bone-marrow-derived cells are required as antigen-presenting cells (APCs) to initiate anti-viral CTL responses. In these APCs, the alternative (exogenous) MHC class I pathway is the obligatory mechanism for the initiation of CTL responses to viruses that infect only non-haematopoietic cells.

Date: 1999
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DOI: 10.1038/18038

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