Retroshuffling the genomic deck

Jef D. Boeke () and Oxana K. Pickeral ()
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Jef D. Boeke: Johns Hopkins University School of Medicine
Oxana K. Pickeral: the National Center for Biotechnology Information, National Institutes of Health

Nature, 1999, vol. 398, issue 6723, 109-111

Abstract: According to the exon-shuffling hypothesis, new genes are assembled from chunks of old ones. But how? A study of the L1 retrotransposon —which usually moves its own sequence from one genomic location to another —suggests a new mechanism. This retrotransposon can co-mobilize a 3' flanking segment of non-L1 DNA to new locations, allowing the juxtaposition of two previously unlinked DNAs.

Date: 1999
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DOI: 10.1038/18118

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