Ageing hard or hardly ageing?

David Kipling () and Richard G. A. Faragher
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David Kipling: University of Wales College of Medicine
Richard G. A. Faragher: University of Brighton

Nature, 1999, vol. 398, issue 6724, 191-193

Abstract: Telomeres have long been suspected to be involved in ageing, and we now have the first direct evidence. Transgenic mice were generated bearing a deletion in themTRgene, which is an essential component of telomerase, the enzyme that maintains telomeres. After six generations of inbreeding, newborn mice show many of the physiological changes associated with normal — but aged — mice.

Date: 1999
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DOI: 10.1038/18306

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