In search of γ-secretase

John Hardy () and Alain Israël ()
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John Hardy: Mayo Clinic Jacksonville
Alain Israël: Unité de Biologie Moléculaire de lExpression Génique, URA 1773 CNRS, Institut Pasteur

Nature, 1999, vol. 398, issue 6727, 466-467

Abstract: The generation of a pathological peptide called Aß is implicated in Alzheimer's disease. Equivalent molecular processes seem to be involved in the Notch signalling pathway that operates during development. New work, centring on molecules called presenilins, shows that the presenilins regulate both Aß production and Notch processing by influencing unusual protein-cleavage events.

Date: 1999
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DOI: 10.1038/18979

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